Finally resolved this, thought I’d post the answer in case someone else has the same issue on a clean Windows 10 install:
• Download and install the Windows 10 driver from Kionix for the accelerometer
○ http://www.kionix.com/downloads
• In the registry, navigate to: HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\ROOT\SENSOR\0000\Device Parameters\kxfusion
• Create a new Binary Value
○ Name: “Orientation”
○ Value: 01 00 00 01 01 00 02
Restart